Transport systems/transporters genes encoding

Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N et al. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nature Genet 1999 21(1) 91 94. 

Zhao, H. and Eide, D. (1996). The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation, Proc. Natl Acad. Sci., 93, 2454-2458. 

The importance of iron for a bacteria-like E. coli can be illustrated by fact that 14 genes alone are required for enterobactin-mediated iron uptake, including those for its synthesis, export, transport of the ferric-enterobactin back into the cell and iron release (Figure 3.16). In total, E. coli has at least 8 uptake systems for iron, encoded by some 50 genes. 

J. Nezu, I. Tamai, A. Oku, R. Ohashi, H. Yabuuchi, N. Hashimoto, H. Nikaido, Y. Sai, A. Koizumi, Y. Shoji, G. Takada, T. Matsuishi, M. Yoshino, H. Kato, T. Ohura, G. Tsujimoto, J. Hayakawa, M. Shimane, and A. Tsuji. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet 21 91-94 (1999). 

Figure 4.1 Nickel transport in . co//.The lower part of the figure shows the nik gene cluster from coli which encodes a nickel specific ABC-type transporter and the repressor protein (NikR).The likely roles of the various nik gene products are indicated in the upper part of the figure.The transporter is encoded by the nikBCDE genes whilst a periplasmic nickel-binding protein is encoded by n/M.The system is expressed when nickel is low. High nickel represses expression via NikR and under these conditions nickel is transported via the Mg transporter (top left).

Lee G, lingsch C, Lyle PT, et al Lithium treatment strongly inhibits choline transport in human erythrocytes. Br J Chn Pharmacol 1 365-370, 1974 Lee KF, li E, Huber J, et al Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral nervous system. Cell 69 737-749, 1992... 

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