Transport positional information

GPCR and transporter protein information from SWISS-PROT has been imported as background data into the Arcadia database. This background information is used in Arcadia to simplify mutant submissions (wild-type proteins are already in the database and therefore do not have to be added by the user residue positions of the mutations... 

As an extension of the preceding discussion about the probable consequences of interactions between auxin waves in branched shoot systems, a control mechanism capable of coordinated growth of all plant parts (axes) can be proposed. Vector fields in the zones of major polar transport of auxin in axes of various orders can be envisioned as morphogenic fields specifying positional information... 

Online sales affect the cost of inventory, facilities, transportation, and information. It is important to observe that the impact in each case is not necessarily positive. 

Characteristically, the mechanisms formulated for azide decompositions involve [693,717] exciton formation and/or the participation of mobile electrons, positive holes and interstitial ions. Information concerning the energy requirements for the production, mobility and other relevant properties of these lattice imperfections can often be obtained from spectral data and electrical measurements. The interpretation of decomposition kinetics has often been profitably considered with reference to rates of photolysis. Accordingly, proposed reaction mechanisms have included consideration of trapping, transportation and interactions between possible energetic participants, and the steps involved can be characterized in greater detail than has been found possible in the decompositions of most other types of solids. 

While the simple stirred tank and plug flow models are adequate to describe convective transport in many cases, a more complete description of fluid flow is sometimes needed. For example, an accurate description of tablet dissolution in a stirred vessel may require information about the changing fluid velocity near the tablet surface. Neither the stirred tank nor the plug flow models can address these velocity changes, since both assume that velocity is independent of position and time. In such cases, a more detailed description of fluid flow can be developed using the Navier-Stokes equations, which describe the effects of pressure, viscos-... 

The latter type of compounds should preferably carry either one type I unit or at most two units (positioned as far apart as possible), and have an elongated structure (which does not fold as verapamil, for example) with a small cross-sectional area, Ad- The first type of compounds is expected to be transported slowly, whereas the second type may not be transported. Table 20.2 summarizes the drug properties relevant for transporter binding and lipid partitioning of a substrate (modulator or inhibitor) of P-gp. Inspection of the information contained in Table 20.2 shows that the synthesis and membrane incorporation of inhibitors with a low number of H-bond acceptor patterns should be simpler and more efficient than that of inhibitors with a large number of patterns. 

We have developed a common residue numbering scheme that facilitates comparison of the sequences of different NTs. The numbering scheme is informative of the relative position of each amino acid, the amino acid present at that position, and the actual amino acid number in a particular transporter. Each index number starts with the number of the transmembrane segment (TM), e.g., 1 for TM1, and is followed by a number indicating the position relative to a reference residue that is the most conserved position in that TM. That reference residue is arbitrarily assigned the number 50. For exam-... 

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