Transmission-blocking malaria

Bathurst, I. C., Barr, P. J., Kaslow, D. C., Lewis, D. H., Atkins, T. J., and Rickey, M. E., 1992, Development of a single mjection transmission-blocking malaria vaccine using biodegradable microspheres, Proc. Int. Symp. Control Rel Bioact. Mater. 19 120-121. 

Kaslow, D., Shiloach, J. (1994) Production, Purification and Immunogenicity of a Malaria Transmission-Blocking Vaccine Candidate TBV25H Expressed in Yeast and Purified using Nickel-NTA Agarose. Biotechnology, 12, 494-499... 

Elimination of centrifugation and filtration in large industrial-scale isolations is a major driving force for the introduction of EBA in the isolation of therapeutic proteins. Streamline chelating (Amersham Pharmacia Biotech) has been tried to purify two vaccine candidates for clinical studies His6-tagged modified diphtheria toxin, expressed in E. coli, and malaria-transmission-blocking vaccine, secreted from S. cerevisiae ... 

Kaslow D.C. and Shiloach J. 1994. Production, purification and immunogenicity of a malaria transmission-blocking vaccine candidate TBV25H expressed in yeast and purified using nickel-NTA agarosa. Biotechnology, 12, 494. 

Lindane is used predominately as a seed dressing and soil insecticide, for the control of ectoparasites of humans and domestic animals, for the control of locusts and grasshoppers, and as a residual spray to control the Anopheles vectors of malaria. Because of its relatively high volatility it is useful to control wood-boring insects of timber, fmit trees, and ornamental plants. The mode of action is not well understood but is thought to be competitive blocking of the y-aminobutyric acid (GABA) transmitter of synaptic nerve transmission. 

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