Translocation Robertsonian

Translocations occur when chromosomes are broken and the broken elements reattach to other chromosomes. Translocations can be classified into two major types, reciprocal and Robertsonian. 

Using mouse-mouse hybrids and Robertsonian translocation markers, Hengart-ner et al. [86] confirmed that the expression of k light chains requires a locus on chromosome 6, whereas the expression of heavy chains required chromosome 12. The formal demonstration that the structural k and Igh loci reside on chromosomes 6 and 12, respectively, was obtained by the analysis of mouse-hamster hybrids using Southern blot hybridization [87,88], A similar approach was used by D Eustachio et al. [89] to assign the A locus to mouse chromosome 16. 

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