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Translesion Synthesis and Immunology Somatic

In addition to facilitating cell survival in the presence of DNA damage and creating genomic variability, somatic hypermutation is another important biological function [Pg.488]

Boudsocq, F., Woodgate, R., and Yang, W. Crystal structure of a Y-family DNA polymerase in action A mechanism for error-prone and lesion-bypass replication. Cell 107, 91-102, 2001. [Pg.491]

Stelter, P., and Ulrich, H. D. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature 425, 188-191, 2003. [Pg.491]

DNA damage-induced mutagenesis A novel target for cancer prevention. Mol. Interv. 1, 269-281, 2001. [Pg.491]

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536 [Pg.493]


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