Translation elongation factor

Abbreviations aa-tRNA Amino-acyl tRNA eLF Eukaryotic translation initiation factor IF Prokaryotic translation initiation factor eEF Eukaryotic translation elongation factor EF Prokaryotic translation elongation factor eRF Eukaryotic translation termination factor (release factor) RF Prokaryotic translation release factor RRF Ribosome recycling factor Rps Protein of the prokaryotic small ribosomal subunit Rpl Protein of the eukaryotic large ribosomal subunit S Protein of the prokaryotic small ribosomal subunit L Protein of the prokaryotic large ribosomal subunit PTC Peptidyl transferase center RNC Ribosome-nascent chain-mRNA complex ram Ribosomal ambiguity mutation RAC Ribosome-associated complex NMD Nonsense-mediated mRNA decay... 

Elongation factor 1-a 40S ribosomal protein s24 Translation elongation factor ip Translation elongation factor 1y Nucleophosmin... 

B.S. Negrutskii and A.V. El skaya. 1998. Eukaryotic translation elongation factor 1 alpha Structure, expression, functions, and possible role in aminoacyl-tRNA channeling Prog. Nucleic Acid Res. Mol. Biol. 60 47-78. (PubMed)... 

Each of these sorts of data also supports the deep split within the archaea, into what Woese, Kandler and Wheelis [10] call Euryarchaeota and Crenarchaeota. What the various data sets do not tell us unequivocally is whether, as a monophyletic assemblage, archaea are more recently diverged from eucarya or instead branch with the bacteria. As chapters in this volume reveal, ribosomal protein genes, those for RNA-polymerase subunits and translation elongation factors and some enzymes of metabolism (HMG-CoA reductase, for example [11]) show strong similarity specifically to their eukaryotic homologs, but others exhibit eubacterial affinities, or seem unique. 

Macbeth, M.R. and Wool, LG. (1999) Characterization of in vitro and in vivo mutations in non-conserved nucleotides in the ribosomal RNA recognition domain for the ribotoxins ricin and sarcin and the translation elongation factors. J Mol Biol, 285, 567-580. 

Translation elongation factors 77.1 23470603 (K)IATDPFVGTLTFVR (K)LAQEDPSFR P. syringae pv. syringae B728a... 

Translation elongation factor J translation inidaii Tion factor elFSo Zn (PDB entry 2E2ti)... 

Most interestingly, PIK-A49 is a multifunctional protein that binds and bundles F-actin and has translational elongation factor-la (EF-la) activity (18). Western blot analysis indicates that PIK-A49 is present in the plasma membrane, cytoskeletal and soluble fractions. GTP and GDP, which affect the -la function of the protein, inhibit the activation of PI 4-kinase by PIK-A49 suggesting that when EF-la functions as an elongation factor it is not functioning as PI 4-kinase activator. 

Yanagisawa T, Sumida T, Ishii R, Ttikemoto C, Yokoyama S (2010) A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P. Nat Struct Mol Biol 17 1136-1143... 

Ude S, Lassak J, Starosta AL et al (2013) Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches. Science 339 82-85... 

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