Transition Metal-Catalyzed Aerobic Oxidations in Continuous Flow

This chapter provides some highhghts in the innovative field of aerobic oxidation reactions in continuous flow. Topics include transition metal-catalyzed aerobic oxidations in continuous flow, photosensitized singlet oxygen oxidation in continuous flow, metal-free aerobic oxidations in continuous flow, aerobic cou-phng chemistry in continuous flow, and general prospects for scale-up. Ozonolysis is not covered in this chapter hereto, we refer to the literature [25—27]. 

Transition Metal-Catalyzed Aerobic Oxidations in Continuous Flow 

R=H 53% 92% yield R=Me 95% yield Bimetallic Au/Pd-lmmobilized capillary column 

The same group reported a second multiphase flow system for the aerobic oxidation of alcohols, catalyzed by bimetallic nanoclusters (Au-Pt and Au-Pd) in a packed-bed configuration [29]. In addition, the direct oxidative methyl ester formation of various aliphatic and benzylic alcohols was achieved, showing much higher yields and selectivities as compared with its batch counterpart. 

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