Transglutaminase biomaterials

Fuchsbauer, H.L. et al.. Influence of gelatin matrices cross-linked with transglutaminase on the properties of an enclosed bioactive material using beta-galactosidase as model system. Biomaterials, 17,1481, 1996. 

The enzymatic tools for functionalization of chitin/chitosan are selected on the basis of the chemical structure of these biopolymers (functional groups and targeted enzyme activities related) and include oxidases, e.g., tyrosinase, peroxidase, laccase and transferase (transglutaminase) types of enzymes. The same enzymatically assisted reactions could be further employed to crosslink the functionalized biomaterials in order to improve their exploitation characteristics, i.e., stability at use. 

Transglutaminase-Mediated Modification of Biomaterials 2.1 TGases, a Family of Enzymes... 

Chau DYS, Collighan R, Verderio E, Addy V, Griffin M (2005) The cellular response to transglutaminase crosslinked collagen. Biomaterials 26 6518-6529... 

Ito A, Mase A, Takizawa Y, Shinkay M, Honda H, Hata KH, Ueda M, Kobayashi T (2003) transglutaminase-mediated gelatin matrices incorporating cell adhesion factors as a biomaterial for tissue engineering. J Biosci Bioeng 95(2) 196-199... 

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