Transformation, of cell cultures

Freeman AE, Weisburger EK, Weisbmger JH, et al. 1973. Transformation of cell cultures as an indication of the carcinogenic potential of chemicals. J Natl Cancer Inst 51(3) 799-807. 

Viral transformation of cell cultures decreases oxygen consumption and increases lactate production (29, 30). An increased rate of gluconeogenesis has been demonstrated in a variety of animal tumors (297) and has been linked to the progressive weight loss syndrome of cancer patients (157), the belief being that actively fermenting neoplastic cells meet their increased glucose requirements at the expense of the host. 

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