Transferases reactions, insects

Multiple forms of GST have been demonstrated in the liver of many mammalian species multiple forms also occur in insects. Most GSTs are soluble dimeric proteins with molecular weights ranging between 45,000 and 50,000 daltons. All forms appear to be nonspecific with respect to the reaction types described, although the kinetic constants for particular substrates vary from one form to another. They are usually named from their chromatographic behavior. At least two are membrane-bound glutathione transferases, one of which is involved in metabolism of xenobiotics and is designated... 

Insect GSH-S-transferases have received a good deal of attention in recent years because of their ability to catalyze the dealkylation and dearylation of a wide variety of organophosphorus insecticides (3,6,41) (Figure 8) as well as y-hexachlorocyclohexane (44). The detoxication reactions that result have been implicated in insect resistance to these insecticides (45,46). 

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