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Transcription factors continued models

Theoretical models of bio-macromolecules are concerned with the development of efficient drugs, the mechanisms of signal transduction, and gene regulation by transcription factors. All these phenomena have in common the capital role played by intermolecular interactions between tlie partners and their ability to recognize patterns. The current developments in structural genomics are, however, continuously... [Pg.301]

Fig. 6. Model for transcripdon Fig. 6. Model for transcripdon<oupled repair in human cells. Transcribing RNA polymerase (RNAP) is blocked by DNA lesions. Two scenarios are plausible and consistent with the available data. To the left is a pathway in which repair factors (XPC is not required) assemble at the lesion site and excise the damage, unaffected by the presence of the stalled polymerase and its transcript. After repair, RNA polymerase continues to translocate and transcribe. The pathway illustrated on the right involves transcripdon termination factor 2 (TTF2), which in an ATP-dependent reacdon, displaces the stalled polymerase TTF2 leaves the DNA, having performed its function. Repair is initiated and proceeds as illustrated in Fig. 4. Mechanistic details for the involvement of CSA and CSB are not known, and thus, they are shown ambiguously between the two pathways. (See Color Insert.)...
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