Transactive response DNA-binding protein

The dentate gyrus is a major site of neuropathology in FTLD-TDP (frontotemporal lobar degeneration with transactive response DNA-binding protein of 43 kDa proteinopathy). Most laminae of the cerebral cortex are affected. CRN mutation cases are quantitatively different from sporadic cases while cases with associated hippocampal sclerosis and AD have increased densities of dystrophic neurites and abnormally enlarged neurons, respectively. There is little correlation between the subjective assessment of subtypes and the more objective quantitative data [98]. Atrophy of the corpus callosum in AD is independent of white matter lesions and may be associated with cognitive deterioration [99],... 

Gendron TF, Josephs KA, PetrucelliL. (2010) Review transactive response DNA-binding protein 43 (TDP-43) mechanisms of neurodegeneration. Neuropathol Appl Neurobiol 36, 97-112. 

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