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TP Receptor Structure

The human TP receptor gene is located on chromosome 19pl3.3 (61X die mouse gene is on chromosome 10 (62) and the rat gene is on chromosome 7ql 1 (63). [Pg.43]

TP receptor gene expression was stimulated by phorbol ester in human megadcaryoblastic leukemia (CHRF-288) cells (6S) and human ISL cells (66), but neither gluco-corticoids [Pg.43]

COIS1XSU8 USMKCSIR nOIIRPrSR PA-JLSQRlUUr ATVeLVHJJUl LAIALULU VORmOXN [Pg.44]

CORSERSOS VBWIVQl-CI MWkSVCHHP UVrikOTVL O-PPAKSP-0 OLSRHI-OL LnLRVkTMl [Pg.44]

Despite the description of several examples of impaired functional and biochemical responses to TP receptor agonists in human and animal platelets (70-76), only one TP receptor mutation has been described (77). A single amino acid substitution (R -L) was found in hxrman TXR-a cDNA obtained by RT-PCR from platelets of patients with a dominantly inherited bleeding disorder (See V. ALTERED TP RECEPTOR FUNCTION, A. TP RECEPTOR MUTATION below). [Pg.45]

See other pages where TP Receptor Structure is mentioned: [Pg.41]    [Pg.43]    [Pg.46]    [Pg.52]   


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