Toxicology of Microtubulin Assembly Inhibitors Pyridines

In rats, dithiopyr is rapidly absorbed, extensively metabolized and rapidly excreted (Table 7-1). Eye irritation in rabbits was slight while skin irritation was nonirritating. Following three weeks of repeated skin exposure to dithiopyr technical, mild transient skin irritation and increased liver weights were the only effects observed in rats. 

Animals quickly metabolize and eliminate thiazopyr (Table 7.1). Rat-liver microorganisms use sulfur and carbon oxidation along with deesterification for degradation. Studies in blueghl sunfish demonstrated 98% elimination within 14 days. 

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