Toxicology allergen tests

Normal toxicological testing for food additives is not necessary and would be too expensive in view of the relatively small amounts of substance used. Nevertheless, toxicological testing of flavoring substances has provided very useful data. Those substances which may cause adverse effects on human health (including allergens) have been identified and have been prohibited or limited in use. 

Identification of chemical respiratory allergens dose-response relationships in the mouse IgE test. Toxicology Methods, 5, 51-60. 

HILTON, J DEARMAN, R.J., BOYLETT, M.S., FIELDING, I., BASKETTER, D. A. KIMBER, I. (1996) The mouse IgE test for identification of potential chemical respiratory allergens. Considerations of stability and controls. Journal of Applied Toxicology, 16,165-170. 

Toxicology LD50 (oral, rat) 16,400 mg/kg mildly toxic by ing. mild allergen causing hay fever, dermatitis, Gl distress, asthma may cause intolerance skin and eye irritant linked to liver damage in test animals TSCA listed... 

Kimber I, Hilton J, Dearman RJ, et al. (1995) An international evaluation of the murine local lymph node assay and comparison of modified procedures. Toxicology 103 63-73 Kligman AM (1966) The identification of contact allergens by human assay III. The maximization test. A procedure for screening and rating contact sensitizers. J Invest Dermatol... 

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