Toxicokinetics warfare

Small, M.J. 1984. Compounds Formed from the Chemical Decontamination of HD, GB, and VX and Their Environmental Fate. Technical Report 8304, AD A149515, US Army Medical Bioengineering Research and Development Laboratory, Fort Detrick, Frederick, MD. Somani, S.M. 1992. Toxicokinetics and Toxicodynamics of Mustard. In Chemical Warfare Agents. A.M. Somani, ed., pp. 13-50, Academic Press, New York. 

Somani, S.M. (1992). Toxicokinetics and toxciodynamics of mustard. In Chemical Warfare Agents (Somani, S.M., ed.). Academic Press, New York. 

Toxicokinetics of Chemical Warfare Agents Nerve Agents and Vesicants... 

The toxicokinetic profile of a chemical warfare agent in mammalian organisms depends on numerous factors, including the nature of the poison, route of exposure, and species differences. Sophisticated study design, modem technical and analytical monitoring tools as well as reliable data from literature are indispensable quality criteria which should be met when performing toxicokinetic studies. The present chapter is focused on this topic. For guidance, we will comment on the stracture of this chapter to provide the reader with an impression of the content. 

Elaboration of toxicokinetic data of chemical warfare agents is essential for designing effective antidotes, improving first aid, and optimizing therapeutic regimen and medical care. It has to be eonsidered that data obtained from in vitro or in vivo animal studies need earefiil extrapolation to humans whieh, at least, requires sophisticated mathematical models to eonsider basie interspecies differenees (Langenberg et ah, 1997 Levy et ah, 2007 Sweeney et al, 2006 Worek et al, 2007). 

Benschop, H.P., De Jong, L.P.A. (2001). Toxicokinetics of nerve agents. In Chemical Warfare Agents Toxicity at Low Levels (S.M. Somani, J.A. Romano, Jr., eds). CRC Press, Boca Raton, FL. 

John, H., et al. (2009) Toxicokinetics of chemical warfare agents nerve agents and vesicants. In Handbook of Toxicology of Chemical Warfare Agents, ediXed by Gupta, R.C. New York Elsevier. 

---