Toxicokinetic-Related Individual Susceptibility Factors

Toxicokinetic-related individual susceptibility factors may in elude individual differences in rates of absorption, concentration at target sites, metabolic activation, and detoxification of individual chemicals. In addition, people can differ in the induction of adaptive protective responses. Genetics, pregnancy, lifestyle factors (such as smoking, alcohol-drinking, and recreational drug 

ACGIH (American Conference of Governmental Industrial Hygienists). 1996. Threshold Limit Values for Chemical Substances and Physical Agents and Bio- 

Andersen, M.E., and H.J. Cle well III. 1984. Pharmacokinetic interactions of mixtures. Pp. 226-238 in Proceedings of the 14th Annual Conference on Environmental Toxicology, 15-17 Nov. 1983, Dayton, OH. AFAMRL-TR-83-099. AD-A146 400. Air Force Aerospace Medical Division, Wright-Patterson AFB, OH. August. 

Andersen, M.E., R. Sarangapani, R.H. Reitz, R.H. Gallavan, I.D. Dobrev, and K.P. Plotzke. 2001. Physiological modeling reveals novel pharmacokinetic behavior of inhaled octamethylcyclotetrasiloxane in rats. Toxicol. Sci. 60(2) 214-231. 

Benignus, V.A., K.E. Mueller, C.N. Barton, and J.A. Bittikoffer. 1981. Toluene levels in blood and brain of rats during and after respiratory exposure. Toxicol. Appl. Pharmacol. 61 (3) 326-334. 

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