Triorganotins toxicity

This process does not generate toxic triorganotin compound (XSn(alkyl)3) in stoechiometric amount but instead inorganic tin-based by-products which are less toxic and easier to eliminate in the work-up ... 

Table 10. Acute Oral Toxicities of Triorganotin Compounds...

The toxicity of the tetraorganotins has beenUtde studied. Available Hterature indicates that tetrabutyltin and the higher tetraalkyltins are substantially less toxic than triorganotins to mammals if taken orally (175). The high toxicity reported for tetraethyltin (LD g = 9 16 mg/kg) appears to be caused by its rapid conversion in the Hver to a triethyl tin species. 

Toxicity of selected diorganotin and triorganotin compounds to zoeae of the marine mud crab (Rithropanopeus harrisii) exposed from hatching to age 14 days... 

Table 8.9 Toxicity of Selected Diorganotin and Triorganotin Compounds to Zoeae of the Marine Mud Crab (Rithropanopeus harrisii) Exposed from Hatching to Age 14 Days...

Snoeij, N.J., A.A.J. Van Iersel, A.H. Penninks, and W. Seinen. 1985. Toxicity of triorganotin compounds comparative in vivo studies with a series of trialkyltin compounds and triphenyltin chloride in male rats. Toxicol. Appl. Pharmacol. 81 2 4-286. 

The difference in partitioning behaviour of triorganotin compounds has implications for their toxic effects [239,240]. The surface-active triphenyltin... 

Hunziker, R. W., Escher, B. I. and Schwarzenbach, R. P. (2002). Acute toxicity of triorganotin compounds different specific effects on the energy metabolism and role of pH, Environ. Toxicol. Chem., 21, 1191-1197. 

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