Toxicity procyanidins

Health consequences of procyanidins in the human diet are relatively unknown, but the toxicity for human beings may be similar to the toxicity observed in experimental animals (12). Bender and Mohammidiha (31) proposed that increased fecal nitrogen from rats fed diets containing large quantities of cooked legumes was due to increased gastrointestinal mucosal cell turnover, rather than poor... 

Acute long term doses of procyanidins and food have a reduced toxicity compared to procyanidin intubated alone. Dietary long term doses of procyanidins are normally encountered in human dietary patterns in various areas of the world. Recommendations to increase common bean consumption will not result in any adverse effects to populations consuming large quantities of beans. 

Recent publications 0,4) in regard to the latter two plants indicate that they were also toxic to two bacteria which occur in the gut of the tobacco budworm Heliothis virescens (Fab.) and the corn earworm Heliothis zea (Boddie). The compounds, rhamnetin 3-0-glucoside and isoquercitrin, were isolated (3) from H camporum based upon their activity against Pseudomonas maltophilia and Enterobacter cloacae Also, a procyanidin was isolated (4) from Mj floribundum on the basis of activity against P. maltophilia. 

To analyze cocoa samples by HPLC, in addition to the long analysis time reported for the analysis of procyanidins with a higher degree of polymerization, when the normal-phase mode was used, the monomers catechin and epicatechin were not resolved. In addition, the use of the unmodified silica column in this normal-phase mode requires the use of toxic chlorinated solvents that are considered an ecological hazard [53]. 

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