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Toxicants, systemic threshold effects

Chlorpromazine Blockade of D2 receptors >> 5 2 receptors .-Receptor blockade (fluphenazine least) muscarinic (M)-receptor blockade (especially chlorpromazine and thioridazine) Hx-receptor blockade (chlorpromazine, thiothixene) t central nervous system (CNS) depression (sedation) t decreased seizure threshold t QT prolongation (thioridazine) Psychiatric schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) nonpsychiatric antiemesis, preoperative sedation (promethazine) pruritus Oral and parenteral forms, long half-lives with metabolism-dependent elimination Toxicity Extensions of effects on a - and M- receptors blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardivedyskinesia, and hyperprolactinemia... [Pg.642]

Systemic Toxicants (Threshold Effects). This area is discussed in more detail elsewhere ( 1, 2) To derive criteria based on noncarcino-genic responses, five types of response levels are considered ... [Pg.452]

As noted above, there are good reasons to believe that there are thresholds of acute toxicants since animals and humans have biochemical defense systems that protect against some toxicants. An adverse effect is detected when the defense system is overwhelmed by some particular dose. However, for some... [Pg.182]

See other pages where Toxicants, systemic threshold effects is mentioned: [Pg.313]    [Pg.365]    [Pg.132]    [Pg.53]    [Pg.10]    [Pg.474]    [Pg.391]    [Pg.95]    [Pg.450]    [Pg.313]    [Pg.365]    [Pg.43]    [Pg.641]    [Pg.675]    [Pg.482]    [Pg.80]    [Pg.486]    [Pg.180]    [Pg.3]    [Pg.4]    [Pg.11]    [Pg.14]    [Pg.22]    [Pg.23]    [Pg.32]    [Pg.38]    [Pg.43]    [Pg.45]    [Pg.55]    [Pg.55]    [Pg.56]    [Pg.57]    [Pg.57]    [Pg.58]    [Pg.59]    [Pg.60]    [Pg.85]    [Pg.97]    [Pg.99]    [Pg.101]    [Pg.105]    [Pg.113]    [Pg.123]    [Pg.125]    [Pg.142]    [Pg.145]   
See also in sourсe #XX -- [ Pg.453 , Pg.454 ]



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Toxicants, systemic

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Toxicity, threshold

Toxicity/toxic effects

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