Toxicant-induced loss of tolerance

The exact mechanism by which chemical exposures cause MCS is unknown. It is believed that a two-step process occurs. First, an initial exposure or chronic exposures interacts with a susceptible individual, leading to loss of that person s prior, natural tolerance for everyday, low-level chemicals, as well as certain foods, drugs, alcohol, and caffeine. In the second stage, symptoms are thereafter triggered by extremely low doses of previously tolerated products and exposures.2 This theory is called toxicant-induced loss of tolerance or TILT. 3... 

MCS stands for multiple chemical sensitivity and is also known as CS (chemical sensitivity), Cl (chemical injury), El (environmental illness), TILT (toxicant-induced loss of tolerance), twentieth-century illness and IEI (idiopathic environmental intolerance). MCS is the most common term for this condition, and is used around the world. 

Professors Ashford and Miller emphasize that the cause of MCS is repeated exposure to toxic chemical substances. They prefer the term TILT, meaning toxicant-induced loss of tolerance, rather than MCS, and they consider TILT a condition that proceeds in two phases. 

Prof. Claudia S. Miller, Toxicant-induced Loss of Tolerance—An Emberging Theory of Disease , University of Texas, Environmental Health Perspectives, 1997, March, 105 Suppl. 2 www.herc. org/news/ehp/miller.html... 

Miller, Claudia S. Toxicant-induced Loss of Tolerance An Emerging Theory of Disease Environmental Health Perspectives, March 1997 105(suppl. 2). www.herc.org/ news/ehp/ miller.html. 

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