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Total Synthesis of Zygosporin

In the first total synthesis of zygosporin E (1195), Vedejs et al. also utilized a.Diels-Alder reaction to form the isoindolone core (739), but used an alternative strategy for stereochemical control at the macrocycle. During the macrocycle construction, a sulfur functionality served as a tool for stereospecific introduction of ring substituents (756, 757). The zygosporin E (1195) route is outlined in Scheme 14.8. [Pg.222]

Vedejs E, Rodgers JD, Wittenberger SJ (1988) A Sulfur-mediated Total Synthesis of Zygosporin E. J Am Chem Soc 110 4822... [Pg.270]


See other pages where Total Synthesis of Zygosporin is mentioned: [Pg.898]    [Pg.224]    [Pg.898]    [Pg.898]    [Pg.224]    [Pg.898]    [Pg.202]    [Pg.270]    [Pg.222]   


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