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Tosylphenylalanine chloromethyl ketone

The active-site-directed inhibitor tosylphenylalanine chloromethyl ketone that specifically and irreversibly inhibits chymotrypsin. This chloroketone inhibitor relies on its toluene sulfonyl (or tosyl) group for binding into the aromatic binding pocket of chymotrypsin s active site. Inactivation occurs by alkylation of histidine-57 (pseudo-first order rate constant 0.2 min ). See Chymo-trypsin... [Pg.681]

TPCK, N-tosylphenylalanine chloromethyl ketone TLCK, N-a-p-tosyl-L-lysine-chloromethyl ketone. [Pg.167]


See other pages where Tosylphenylalanine chloromethyl ketone is mentioned: [Pg.477]    [Pg.477]    [Pg.477]    [Pg.477]   


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