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Topoisomerase 1-inhibitory propertie

Moreau P, Gaillard N, Marminon C, Anizon F, Dias N, Baldeyrou B, Bailly C, Pierre A, Hickman J, Pfeiffer B, Renard P, Prudhomme M (2003) Semi-Synthesis, Topoisomerase I and Kinase Inhibitory Properties, and Antiproliferative Activities of New Rebeccamycin Derivatives. Bioorg Med Chem 11 4871... [Pg.446]

Lapachol, an alcohol that can be converted into P-lapachone (21), a prenyl-naphto-l,2-quinone known for its anti-tumoral, pro-apoptopic and topoisomerase I-inhibitory properties was obtained from the lapacho tree, Tabebuia avellanadae (Bignoniaceae). Although an inhibition of PTKs has not, to our knowledge, been reported, P-lapachone inhibited the activation of INK and MEK by tumour necrosis factor (TNF). These effects may account for the observed inhibition of the NF-KB-mediated gene expression and the mentioned biological activity [71],... [Pg.851]

See other pages where Topoisomerase 1-inhibitory propertie is mentioned: [Pg.177]    [Pg.182]    [Pg.185]    [Pg.88]    [Pg.79]    [Pg.154]   
See also in sourсe #XX -- [ Pg.851 ]

See also in sourсe #XX -- [ Pg.27 , Pg.851 ]

See also in sourсe #XX -- [ Pg.851 ]



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Inhibitory properties

Topoisomerase

Topoisomerase inhibitory

Topoisomerases

Topoisomerases properties

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