Tabebuia avellanadae

Lapachol, an alcohol that can be converted into P-lapachone (21), a prenyl-naphto-l,2-quinone known for its anti-tumoral, pro-apoptopic and topoisomerase I-inhibitory properties was obtained from the lapacho tree, Tabebuia avellanadae (Bignoniaceae). Although an inhibition of PTKs has not, to our knowledge, been reported, P-lapachone inhibited the activation of INK and MEK by tumour necrosis factor (TNF). These effects may account for the observed inhibition of the NF-KB-mediated gene expression and the mentioned biological activity [71],... 

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See also in sourсe #XX -- [ , , , , , ]

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