Topiramate Hormonal contraceptives

Preliminary results of a study show that rufinamide 800 mg twice daily for 14 days decreased the AUC of ethinylestradiol 35 micrograms hy 22% and of norethisterone 1 mg by 14% in healthy women taking a combined oral contraceptive. Inhibition of ovulation was not assessed. These reductions in plasma levels of the contraceptive hormones are similar to those seen with topiramate (see Hormonal contraceptives + Antiepileptics Topiramate , below), and their clinical relevance is unknown. However, given these findings, low-dose contraceptives (ethinylestradiol 20 micrograms) may be considered unsuitable for use with rufinamide. Further study is needed. 

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