Tools for Increasing Productivity in Combinatorial Chemistry

Medicinal chemistry, being largely an experimental discipline, is often a tedious and labor-intensive process, which requires attention of highly skilled specialists to seemingly simple synthetic procedures. Therefore, it is always desirable to automate the synthesis process, allowing the scientists to concentrate on more intellectually demanding activities. Combinato- 

The scope of the methods practiced in modern combinatorial chemistry is very large. Compounds are synthesized in solution and on solid phase, in a wide range of quantities large and small, encoded and unencoded libraries fit different needs of the drug discovery process. Chemistry optimization is more demanding in the case of combinatorial chemistry. Optimal conditions for the reliable and high-yield synthesis of all library members should be discovered through experimentation. 

The following section will describe some manual and automated devices that can improve the productivity of different types of combinatorial chemistry approaches. 

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