Tonic Suppression of iNOS Induction by Endogenous Glucocorticoids

Tonic Suppression of iNOS Induction by Endogenous Glucocorticoids 

There is now good evidence that enhanced formation of NO by iNOS importantly contributes to the circulatory shock (hypotension and vascular 

FIGURE I (top) Mean arterial blood pressure and (bottom) iNOS activity in the lungs of normal Wistar rats (Control) and adrenalectomized (ADX) rats prior to and 120 min after receiving lipopolysaccharide (LPS) (0.1 mg/kg) as well as at 120 min after LPS in ADX rats pretreated with dexamethasone (10 mg/kg) (DEX+ADX) n = 3-6). Data are expressed as the means SEM of observations. 

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A. Tonic Suppression of iNOS Induction by Endogenous Glucocorticoids... 

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