Tolerance phencyclidine

Flint, B.A. and Ho, I.K. Tolerance development to phencyclidine by chronic administration. Prog Neuropsvchopharmacol 4 233-239,... 

Freeman, A.S. Martin, B.R. and Balster, R.F. Relationship between the development of behavioral tolerance and the biodisposition of phencyclidine in mice. Pharmacol Biochem Behav 20 373-377, 1984. 

Woolverton, W.L., and Balster, R.L. Tolerance to the behavioral effects of phencyclidine Importance of behavioral and pharmacological variables. Psvchopharmacoloav (Berlin) 64 19-24,... 

Tolerance to the effects of phencyclidine develops in both animals and man. A slight physical dependence has been reported in man, characterized by a craving for the drug, persistent amnesia, slurred speech and difficulty in thinking, which may last up to 1 year after discontinuing the drug. Severe personality changes have also been reported. 

Cognitive decline, depression, anxiety, violent behavior, and weight loss are reported following chronic use of phencyclidine. Prolonged psychosis has been reported, which can mimic acute schizophrenia, and can persist for 4-6 weeks. Tolerance to the psychoactive effects can lead abusers to take increased doses. Psychological dependence has been noted, but no distinct withdrawal symptoms have been reported. 

Nalbuphine is less likely to depress respiratory function than meperidine Tolerance to ocular and gastrointestinal effects develops rapidly during chronic use Mental retardation, microcephaly, and underdevelopment of the mid face region in an infant is associated with chronic maternal abuse of (A) Amphetamine Cocaine Ethanol Mescaline Phencyclidine... 

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