Tolazoline interaction

Clinically important, potentially hazardous interactions with acenocoumarol, alfuzosin, aminophylline, anisindione, anticoagulants, buprenorphine, butorphanol, caffeine, carmustine, dobazam, cocoa, dicumarol, dofetilide, duloxetine, epirubicin, eszopiclone, fentanyl, floxuridine, fluorouracil, galantamine, gliclazide, hydromorphone, itraconazole, ketoconazole, lidocaine, meptazinol, midazolam, mizolastine, modobemide, morphine, narcotic analgesics, oxprenolol, oxycodone, pentazocine, phenytoin, posaconazole, prednisone, propranolol, sufentanil, tolazoline, warfarin, xanthines, zaleplon, zofenopril, zolmitriptan, zolpidem... 

Information is limited but this interaction would appear to be established. The authors of this report warn that an infusion of dopamine should not be considered for several hours after even a small single dose of tolazoline has been given. They point out that impaired renal function often accompanies severe respiratory failure, which may significantly prolong the effects of tolazoline. 

Tolazoline dilates the pulmonary vascular system by stimulating both Hp and H2-receptors. Cimetidine and ranitidine block H2-receptors so that at least part of the effects of tolazoline are abolished. It has been suggested that this interaction is confined to children. ... 

An established interaction. Cimetidine and ranitidine are not suitable drugs for prophylaxis of the gastrointestinal adverse effects of tolazoline in children. Other H2-receptor antagonists would be expeeted to behave similarly. 

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