Tocainide hydrochloride

Infra-red Spectrum. Principal peaks at wavenumbers 1675,1540, 765, 1128, 772, 1240 (tocainide hydrochloride, KBr disk). 

Tocainide hydrochloride, 1028 Toclase, 431 Tocomine, 329 Tocopherol acetate, 329 Tocopheryl acetate, 329 Tofenacin, 1028 (metabolite), 833 Tofenacin hydrochloride, 1028 Tofranil, 679 Tofranil-PM, 679 Togiren, 589 Toilax, 397 Tokols, 329 Tolanase, 1029 Tolazamide, 1029 Tolazoline, 1029 Tolazoline hydrochloride, 1029 Tolbutamide, 1030 Tolbutamide sodium, 1030 Tolbutone, 1030 Tolectin, 1032 Tolerance to drugs, 298 Tolerzide, 663 Tolerzide, 971 Tolfenamic acid, 1031 Tolglybutamide, 1030... 

Anonymous. Tocainide hydrochloride pulmonary fibrosis. Swed Adv Drug React Adv Comm Bull 1988 54. 

Tocainide hydrochloride is clus.sed a.s a IB antiarrhyihnuc agent and used orally to prevent or treat ventricular cctnpy and tachycardia. The drug is given in 400- to 600-mgdo ies every 8 hours. 

It has been established that the total body clearance of tocainide hydrochloride stands at 166 mL. min only thereby suggesting that the hepatic clearance is not to an appreciable extent. By virtue of the fact that the drug has very low hepatic clearance, the prevailing hepatic extraction ratio should be quite small and hence, the drug is most unlikely to afford a sizable first pass eifect. It gets hydrolyzed in a manner very much akin to lidocaine and as such its metabolites are active. 

Physical Parameters. The physical parameters of the ( )-Tocainide hydrochloride, CjjH gN20.HCl, obtained as crystals fi om a mixture of ethanol/ether, have mp ranging between 246-247°C. 

C)jHi)N 87-62-7) see Bupivacaine Etidocaine LicIocaine Lidoflazine Mepivacaine Pilsicainide Pyrrocaine Ropivacaine hydrochloride Tocainide Xipamide... 

Mexiletine Hydrochloride. Mcxiletinc hydrochloride. l-methyl-2-(2.6-xylyloxy)cthylamine hydrochloride (Mexi-til) (pK.., 8.4), is a class IB ontiarrhythniic agent that is cffec-tive when given either intravenously or orally. It re.sembles lidocaine in po.ssessing a xylyl moiety but otherwise is diTfer-ent chemically. Mexiletine hydrochloride is an ether and is not subject to the hydrolysis common to the amides lidocaine and tocainide. Its mean half-life on oral administration is approximately 10 hours. 

Lignocaine has already been diseussed under local anaesthetics and it is also found to possess anti-arrhythmic actions. There are a few other synthetic compormds which exhibit lignocaine-like properties, e.g., mexiletine hydrochloride tocainide which shall be discussed as rmder ... 

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