Tobramycin serum concentration monitoring

The aminoglycosides (i.e., amikacin, gentamicin, and tobramycin) and vancomycin remain the most common agents for which serum concentrations are monitored. A summary of the recommendations for serum concentration monitoring of these agents is shown in Table 103-2. 

Monitoring In patients with normal renal function, serum tobramycin concentrations are approximately 1 mcg/mL 1 hour after dose administration. Monitoring of serum concentrations in patients with renal dysfunction or patients treated with concomitant parenteral tobramycin may reduce the risk of toxicity. 

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