TMDI theoretical maximum daily intake

TMDI (Theoretical Maximum Daily Intake) will be calculated as follows TMDI=X[MRLiXFJ... 

When calculating chronic dietary exposure, the deterministic models use point values for both food consumption and residue concentration, thereby yielding a point estimate of dietary exposure. In the US, the initial chronic dietary exposure estimate is the Theoretical Maximum Residue Contribution (TMRC) and is analogous to the Theoretical Maximum Daily Intake (TMDI) used to estimate chronic dietary exposure in the EU. Both the TMRC and the TMDI are relatively conservative estimates of dietary expostire. The TMRC is calculated as the product of the mean consumption value and the US pesticide tolerance [6]. In the EU, the TMDI is calculated as the product of the mean consumption value and the Maximum Residue Limit (MRL) [7]. The objective of both calculations is essentially identical to calculate an estimate of the central tendency of the dietary exposure. Both calculated values use the central tendency dietary exposure estimate as the estimate of chronic (long-term) dietary exposure and calculate it using mean consumption data and the maximum residue permitted on the commodity. 

On the basis of the food basket, the EU authority (EMA/CVMP) then requires applicants for MAs to estimate the theoretical maximum daily intake (TMDI) for persons weighing 60 kg, applying the equation ... 

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