Titanium tetra-wo-propoxide

Enantioselective epoxidation of allylic alcohols using t-butyl peroxide, titanium tetra-wo-propoxide, and optically pure diethyl tartrate. [Pg.533]

APTMS-modified MCM-41 surface. In a last step, titanium tetra-wo-propoxide reacted with the chiral organic-inorganic hybrid material, to give the heterogeneous variant of the asymmetric epoxidation catalyst of allylic alcohols, proposed by Katsuki and Sharpless.312... [Pg.93]

One of the most important asymmetric syntheses is the Sharpless epoxidation. In this reaction, an allylic alcohol is transformed, by reaction with rerf.-butyl hydroperoxide (TBHP) in the presence of titanium tetra-wo-propoxide (Ti(/-PrO)4) and diethyl tartrate (DET), to the corresponding epoxy alcohol, with high enantiomeric purity. By the application of either (+)- or (-)-DET, the reaction product with the desired stereochemistry can be obtained [1,2] (Scheme 1). "O" (-)-DET... [Pg.315]

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