Tissue synchronization imaging

Yu CM, Zhang Q, Fung JW, et al. A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging. J. Am. Coll. Cardiol. 2005 45 677-84. 

Gorcsan J, 3rd, Kanzaki H, Bazaz R, Dohi K, Schwartzman D. Usefulness of echocardiographic tissue synchronization imaging to predict acute response to cardiac resynchronization therapy. Am J Cardiol 2004 93 1178-81. 

An example of high-contrast resonant imaging of tissue structures with this source is shown in Figure 5.4a. Here, the white adipose tissue of a mouse omentum majus is imaged at a depth of -10 pm from the surface at a Raman shift of 2850 cm ( ump = 924 nm A tokes = 1254 nm). In contrast, for the same Raman shift, two synchronized Ti sapphire lasers (Potma et al. 2002) would typically have pump and Stokes wavelengths of -710 nm and -890 nm, respectively, and are much more strongly scattered in turbid tissue. 

Strong AJ, Fabricius M, Boutelle MG, Hibbins SJ, Hopwood SE, Jones R, Parkin MC, Lauritzen M (2002) Spreading and synchronous depressions of cortical activity in acutely injured human brain. Stroke 33 2738-2743 Szafer A, Zhong J, Anderson AW, Gore JC (1995) Diffusion-weighted imaging in tissues theoretical models. NMR Biomed 8 289-296... 

Movie A video showing the hybrid culture grown on top of the micro-electrode array plate. The image is shown at a high magnification (x40). Note the synchronous contractions of the hES cell-derived cardiomyocyte tissue (cell cluster on the right side of the image) and the neonatal rat ventricular myocyte monolayer. 

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