Tissue necrosis phenol

Sclerosing agents. Chemicals may be used to cause inflammation and thrombosis in veins so as to induce permanent obliteration, e.g. ethanolamine oleate injection, sodium tetradecyl sulphate (given i.v. for varicose veins) and oily phenol injection (given submucously for haemorrhoids). Local reactions, tissue necrosis and embolus can occur. 

Gastritis, vomiting, and diarrhea are followed by depression, unconsdousrress, or mild sdzures phenol causes tissue necrosis, tremors and mild seizures followed by depression and renal tubular recrods... 

Phenol poisoning can occur in humans after skin absorption, inhalation of vapours or ingestion. Acute local effects are severe tissue irritation and necrosis. At high doses, the most prominent systemic effect is central nervous system depression (lARC, 1989). 

---