Tissue engineering scaffolds rapid prototyping

Keywords— Tissue engineering, scaffold, process parameter, rapid prototyping, extrusion. 

Chen, M., Le, D., Hein, S., et al., 2012. Fabrication and characterization of a rapid prototyped tissue engineering scaffold with embedded multicomponent matrix for controlled drug release. International Journal of Nanomedicine 7,4285-4297. 

R. De Santis, A. Gloria, T. Russo, U. D Amora, V. D Anto, F. Bollino, L. Ambrosio, et al.. Advanced composites for hard-tissue engineering based on PCL/organic-inorganic hybrid fillers from the design of 2D substrates to 3D rapid prototyped scaffolds. Polymer Compos. 34 (2013) 1413-1417, doi 10.1002/pc.22446. 

Landers R, HUbner U, Schmelzeisen R, Miilhaupt R. Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering. Biomaterials 2002 23(23) 4437. 

These techniques have several drawbacks, such as the extensive use of highly toxic organic solvents, and long fabrication periods. Therefore, more recent rapid prototyping techniques have been utilized by tissue engineers to produce three-dimensional porous scaffolds (38). 

Yang SF, Leong KF, Du ZH, Chua CK. The design of scaffolds for use in tissue engineering. Part n. Rapid prototyping techniques. Tissue Eng 2002 8 1—11. 

Wilson, C., De Bruijn, J., Van Blitterswijk, C., Verbout, A., Dhert, W., 2004. Design and fabrication of standardized hydroxyapatite scaffolds with a defined macro-architecture by rapid prototyping for bone-tissue-engineering research. J. Biomed. Mater. Res. A 68 (1), 123-132. 

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