Tincture of opium

Treatment of severe diarrhea and intestinal cramping (camphorated tincture of opium)... 

Octreotide (Sandostatin, Sandostatin LAR) Paregoric [Camphorated Tincture of Opium]... 

Paregoric [Camphorated Tincture of Opium] [C lll] [Narcotic Antidiarrheal] Uses D, Pain neonatal opiate withdrawal synd Action Narcotic Dose Adults. 5—10 mL PO daUy-qid PRN Peds. 0.25-0.5 mL/kg daily-qid Neonatal withdrawal 3-6 gtt PO q3-6 h PRN to relieve Sxs x 3-5 d, then taper ovo 2-4 wk Caution [B (D w/ prolonged use/high dose near term, +]... 

Opium Street Names Auntie Emma, big O. black stuff, block, gum, hop, ope, tar (brand generic called tincture of opium, laudanum, paregoric (CIII), B O suppositories [CIII]) Use Some medical uses (antidiarrheal, antitussive, antispas-modic) illegally used to produce morphine and h oin can be swallowed or smoked Actions Narcotic contains morphine Effects Pain relief, euphoria, drowsiness/N, constipation, confusion, sedation, resp dqjression and arrest, tol -ance, addiction, unconsciousness, coma, death... 

The use of opium dates to 4,000 b.c. At that time it was used for medicinal and recreational purposes mainly via inhalation. Today few opium-containing preparations are used, since the activity of opium is largely attributed to its morphine content. The preparations in use today are those that have constipative effects useful for the treatment of diarrhea. Preparations include pantopon, an injectable hydrochloride of opium alkaloids, and paregoric, a camphorated tincture of opium. Paregoric can be used to treat infants with opioid withdrawal signs following in utero exposure to opioids. 

Tincture of opium (10% opium) is a rapidly acting preparation for the symptomatic treatment of diarrhea. 

Laudanum was any of a number of tinctures or mixtures of opium with other materials. In the nineteenth century tincture of opium was given the acronym GOM (God s Own Medicine). Opium was smoked and eaten recreationally and to boost the output of natives at hard labor thoughout the Near and Far East for hundreds of years. 

The alchemical philosopher and physician Paracelsus writes about the use of tincture of opium as a medicine. 

In the process of preparing a tincture, some pharmacologically active constituents of the plant are extracted by the alcohol. Although not all substances are soluble in alcohol, those that are include the alkaloids. In the case of a tincture of raw opium, the soluble alkaloids include morphine, codeine, noscapine, and papavarine. Such tinctures of opium were the infamous laudanum preparations of the late 1800s (see Appendix). 

Paracelsus abandoned all this witchcraft and superstition. He started the search for the potent drugs which the alchemist was to prepare or purify. Even the many herbs and extracts in common medical use were placed secondary to the value of these chemicals. There were many who gave ear to his instructions They went back to their laboratories, threw away the crucibles filled with the strange concoctions that would not change to gold, and sought medicines to relieve human suffering. Paracelsus himself showed the way. He experimented in his laboratory, and introduced into medicine salves made from the salts of mercury. He was the first to use tincture of opium, named by him laudanum, in the treatment of disease. The present pharmacopoeia includes much that Paracelsus employed —lead compounds, iron and zinc salts, arsenic preparations for skin diseases, milk of sulfur, blue vitriol, and other chemicals. 

Opium can be taken by mouth or it can be smoked, but since smoking was unknown in Europe and Asia until Columbus brought news of it from the New World, opium smoking did not exist before 1492. Many oral preparations of opium were made in the past. Two that survive into our own times are paregoric, a dilute tincture of opium combined with camphor, and deodorized tincture of opium, formerly known as laudanum, which is more, concentrated. 

R Olei Ricini [castor oil] f iss Tincturae Opii [Tincture of opium] ITf xxx Pulv. Acaciae [powdered acacia],... 

Natural opioids, that is, opioids extracted directly from opium include codeine—used for dental and other postoperative pain laudanum, paregoric—a mild tincture of opium mixed with camphor and used primarily for control of diarrhea and morphine. Heroin is a partial synthetic that combines morphine and diacetyl... 

Papaver somniferum (opium poppy) contains a variety of opioid and related alkaloids, including codeine, morphine, noscapine, papaverine, and thebaine. Crude opium is the air-dried latex obtained by incising the unripe capsules of P. somniferum. Paregoric is ammoniated tincture of opium (Scotch paregoric) or camphorated tincture of opium (English paregoric). The use of these formulations has largely been replaced by use of the purified compounds. 

Schoen AM (1984) Tincture of opium. New England Journal of Medicine 310(17) 1124. 

The constipating effect of orally administered opiates can be used for the treatment of diarrhea, as with camphorated tincture of opium (Paregoric or Parepectolin, which is a paragoric plus kaolin as an adsorbent and pec-... 

The opiates are perhaps the oldest drugs known to man. The use of opium was recorded in China over two thousand years ago and was known in Mesopotamia before that. Over the centuries the crude extract derived from poppies has been widely used as a sedative. A tincture of opium called laudanum was introduced to England and was considered indispensable to medicine. It is ironic that a compound renowned for its sedative effects should have led to at least one war. In the nineteenth century, the Chinese authorities became so alarmed about the addictive properties of opium that they tried to ban all production of it. This was contrary to the interests of the British traders dealing in opium and as a result the British sent in the gunboats to reverse the... 

Paregoric, tincture of opium, is marketed as a 2 mg/5 mL solution and is indicated for managing both acute and chronic diarrhea. It is not widely prescribed today because of its abuse potential. 

Laudanum Formerly, any of various preparations of opium now a tincture of opium. 

Paregoric A medicine that eases oeln. Usually refers to tincture of opium. 

Caz horated Tincture of Opium. (Paregoric Elixir). This is a camphorated tincture of opium. Macerate X drachm each powdered opium and benzoic acid, 1 fluid drachm oil of anise, 2 ounces clarified honey, and 2 scruples camphor, in 2 pints dilut alcohol for 7 days, and filter through paper. (27. S. Ph.)... 

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