Time-of-flight system

Tiller, P. R., Yu, S., Castro-Perez, J., Fillgrove, K. L., and Baillie, T. A. (2008). High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a first-line approach for metabolite identification studies. Rapid Commun. Mass Spectrom. 22 1053-1061. 

Campbell, J.M., Collins, B.A., and Douglas, DJ. (1998). A Linear Ion Trap Time-of-flight System with Tandem Mass Spectrometry Capabilities, Rapid Commun. Mass Spectrom., 12,1463-1474. 

Collings, B.A. Campbell, J.M. Mao, D.M. Douglas, D.J. A combined linear ion trap time-of-flight system with improved performance and MS" capabilities. Rapid Commun. Mass Spectrom. 2001,15, 1777-1795. 

Fig. 12.9 Time-Of-Flight system (TOF) (left) measures the time required for a laser pulse to travel to and return from an object. Continuous wave system (right) is a variation on the TOF method distance is computed by comparing the phase shift between an emitted wavelength and the received light [18]...

With SANS the camera length is fixed, but the pulsed time-of-flight system provides measurements in roughly the same colloidal range. 

A study of transformation products of triazines in environmental waters was performed by directly injecting 50 xL in an LC-ESI-QTOF (quadrupole-time-of-flight) system [129]. The high sensitivity in the full-scan mode allowed elucidating minor metabolites even below 2% of the total peak area. Furthermore, the MS/MS capability of this tandem instrument was very useful for differentiating isomeric transformation products from each other. 

Campbell, J. M. Collings, B. A.,et al. A new linear ion trap time-of-flight system with tandem mass spectrometry capabilities. Rapid Commun. Mass Spec. 1998, 12, 1463-1474. 

Figure 3.3.30 Two-dimensional blocking pattern obtained with a time-of-flight system and a microchannel plate detector. This is a relatively new but very promising approach to MEIS as it provides a comprehensive two-dimensional image of the blocking pattern [43].

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