Tobramycin Ticarcillin

Klastersky J, Hensgens C, Debusscher I. Empiric therapy for cancer patients comparative study of ticarcillin-tobramycin, ticarcillin-cephalothin, and cephalotin-tobramycin. Antimicrob Agents Chemother 1975 7 640-645. 

Noninterfering acetaminophen, amikacin, ceftazidime, ceftriaxone, genteimicin, nafcillin, phenytoin, ticarcillin, tobramycin, vancomycin... 

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, ampicil-lin, carbamazepine, cefamandole, cefazolin, cefoperazone, cefotaxime, cefoxitin, ceftazidime, ceftizoxime, cephalexin, cephalothin, cephapirin, chloramphenicol, ciprofloxacin, clonazepam, (yclosporine, desipramine, digoxin, disopyramide, ethosuximide, gentamicin, haloperidol, imipramine, kanamycin, lidocaine, mezlocillin, netilmicin, nortriptyline, phenobarbital, phenytoin, primidone, procainamide, propranolol, quinidine, salicylic acid, streptomycin, sulfamethoxazole, theophylline, thiamphenicol, ticarcillin, tobramycin, trimethoprim, vancomycin... 

Aninoglycosides Gentamicin Tobramycin Amikacin Penicillins Ampicillin Ampicillin-sulbactam Ticarcillin-davulanate Piperacillin-tazobactam Cephalosporins, first-, second-, and third-generation... 

In ophthalmology, both trans-scleral and transcomeal dmg delivery has been studied. Drags investigated include fluorescein, tobramycin, gentamicin, ticarcillin, cefazolin, dexamethasone and ketoconazole. Iontophoresis has been found to be both safe and effective in delivering the required doses locally, at the intended site of action. Excepting for lidocaine, which has been tested in human volunteers, all the other drags have been tested in rabbits. 

English J, Gilbert DN, Kohlhepp S, Kohnen PW, Mayor G, Houghton DC, Bennett WM. Attenuation of experimental tobramycin nephrotoxicity by ticarcillin. Antimicrob Agents Chemother 1985 27(6) 897-902. 

Matzke GR, Luckham DR, Collins AJ, Halstenson CE. Effect of ticarcillin on gentamicin and tobramycin pharmacokinetics in a patient with end-stage renal disease. Pharmacotherapy 1984 4 158-160. 

A fluoroquinolone a tetracycline gentamicin A fluoroquinolone amikacin a tetracycline trimethoprim-sulfamethoxazole cefotaxime, ceftizoxime, ceftriaxone, cefepime, or ceftazidime Gentamicin, tobramycin or amikacin trimethoprim-sulfamethoxazole ciprofloxacin, ticarcillin, mezlocillin, or piperacillin aztreonam cefotaxime ceftizoxime ceftriaxone cefepime or ceftazidime Ampicillin gentamicin, tobramycin, or amikacin carbenicillin, ticarcillin, mezlocillin, or piperacillin gentamicin, tobramycin, or amikacin amoxicillin/clavulanic acid ticarcillin/clavulanic acid piperacillin/tazobactam ampicillin/sulbactam trimethoprim-sulfamethoxazole imipenem or meropenem aztreonam a fluoroquinolone another cephalosporin... 

An aminoglycoside ciprofloxacin trimethoprim-sulfamethoxazole ticarcillin, mezlocillin, or piperacillin ceftazidime minocycline doxycycline sulbactam polymyxin Gentamicin or tobramycin imipenem a fluoroquinolone Doxycycline azithromycin... 

Ticarcillin, mezlocillin, or piperacillin tobramycin, gentamicin, or amikacin Penicillin G... 

Other reports similarly describe unusually low gentamicin levels in patients with impaired renal function, given carbenicillin, piperacillin," or ticarcillin. > >" The half-life of gentamicin has been reported to be reduced by carbenicillin or piperacillin by about one-half or one-third. >">" Similarly, unusually low tobramycin levels have been reported in patients with impaired renal function, who were given carbenicillin, piperacillin or ticarcillin."... 

No interaction was seen in 10 patients given tobramycin with piperacillin, or in another 10 healthy subjects given once daily gentamicin with piperacillin/tazobactam. Only minimal pharmacokinetic changes were seen in 9 healthy subjects given tobramycin with piperacillin/tazobactam, and 18 cystic fibrosis patients (adults and children) given tobramycin with ticarcillin."... 

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