Ticarcillin Methotrexate

Clinically important, potentially hazardous interactions with amoxicillin, ampicillin, antacids, bacampicillin, calcium carbonate, carbenicillin, cloxacillin, digoxin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, ticarcillin, zinc... 

Clinically important, potentially hazardous interactions with acitretin, aluminum hydroxide, amoxicillin, ampicillin, antacids, bacampicillin, betamethasone, bismuth, bromelain, calcium, carbenicillin, cholestyramine, doxacillin, corticosteroids, dairy products, dicloxacillin, didanosine, digoxin, food, glidazide, iron, isotretinoin, methicillin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, retinoids, rocuronium, strontium ranelate, sucralfate, ticarcillin, vitamin A, zinc... 

Reduced clearance and acute methotrexate toxicity has been attributed to the concurrent use of various penicillins (amoxicillin, benzylpenicillin, carbenicillin, dicloxacillin, flucloxacillin, mezlocillin, oxacillin, penicillin, phenoxymethylpenicillin, piperacillin, ticarcillin) in a small number of case reports. 

Intravenous bolus 15 to 60 mg/m, then 15 to 60 mg/m intravenous infusion over 36 hours Ticarcillin (not stated) Acute Myeloid Leukaemia (1) 60% reduction in methotrexate clearance prolonged folinic acid rescue necessary 3... 

---