Tiapride Alcohol

Tiapride Alcohol Tiapride is a dopamine receptor D2 and D3 antagonist. It is used to treat alcohol withdrawal syndrome where it has anxiolytic effects. Tiapride has been shown to reduce psychological stress, decrease drinking, and improve reintegration into society [252]. 

Dissection of the molecular mechanisms underlying tobacco addiction should lead to new and better treatments to achieve nicotine withdrawal. It seems clear that the dopamine D2 receptor is involved in nicotine dependence and drugs that block this receptor, such as tiapride, could be useful in the treatment of tobacco dependence. Tiapride has been shown to be successful in alcohol withdrawal [58] but would represent a new avenue for tobacco addiction therapy. 

A 34-year-old alcoholic man with acute pancreatitis was given continuous intravenous infusion of haloperidol (2 mg/hour) for agitation after 7 hours he received a bolus dose of haloperidol 10 mg for worsening agitation and 20 minutes later, QT interval was 560 ms (420 ms before treatment) (131). He developed torsade de pointes and ventricular fibrillation, which resolved with electric defibrillation. He was a smoker and was also taking tiapride and alprazolam for depression, in addition to pantoprazole, piperazilline + tazobactam, paracetamol, and vitamins Bi, B6, and B 12-... 

Tiapride appears to be useful in alcohol withdrawal as an alternative to the benzodiazepines (2). It facilitates the management of ethanol withdrawal, but its use in patients at risk of severe reactions in acute withdrawal should be accompanied by adjunctive therapy for hallucinosis and seizures. Since it may prove difficult to identify such patients and since there is also a small risk of the neuroleptic malignant syndrome (particularly with parenteral administration), the usefulness of tiapride in this setting is likely to be limited. The potential risk of tardive dyskinesia at the dosage used in alcoholic patients following detoxification (300 mg/day) requires evaluation and necessitates medical supervision. It is unlikely to produce problems of dependence or abuse. 

Peters DH, Faulds D. Tiapride. A review of its pharmacology and therapeutic potential in the management of alcohol dependence syndrome. Drugs 1994 47(6) 1010-32. 

The detrimental effects of alcohol on the skills related to driving are made worse by chlorpromazine, and, to a lesser extent, by flu-pentixol, sulpiride and thioridazine. Small or single-dose studies with haloperidol or tiapride surest that any interaction would seem to be mild nevertheless, all antipsychotic drugs which cause drowsiness have the potential to enhance the effects of alcohol. There is evidence that drinking can precipitate the emergence of extrapyramidal adverse effects in patients taking antipsychotics. 

A study in 9 alcoholics given tiapride 400 to 600 mg daily showed that wakefulness was not impaired when alcohol 0.5 g/kg was given, and in fact appeared to be improved, but the effect on driving skills was not studied. ... 

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