Thyroid peroxidase antibodies

Thyroid peroxidase antibodies (TPA) < 0.8 IU/mL Often present Usually present... 

The complexity of the interaction between iodine intake and autoimmune thyroid disease has been highlighted by reports of evidence that iodide (compared with thyroxine) induces thyroid autoimmunity in patients with endemic (iodine deficient) goiter (43), while in those with pre-existing thyroid autoimmunity, evidenced by the presence of antithyroid (thyroid peroxidase) antibodies, administration of iodine in an area of mild iodine deficiency led to subclinical or overt hypothyroidism (44). 

After 6 months of treatment, 12% of patients with chronic hepatitis C had thyroid disorders, compared with 3% of patients with chronic hepatitis B. This study also suggested a possible relation between low free triiodothyronine serum concentrations before treatment and the subsequent occurrence of thyroid dysfunction. After a follow-up of 6 months after the end of interferon alfa treatment, 60% of affected patients with chronic hepatitis C still had persistent thyroid dysfunction all had been positive for thyroid peroxidase antibodies before treatment. Long-term surveillance is therefore needed in these patients. 

Gartner R, Gasnier BCH, Dietrich JW, Krebs B and Angstwurm MWA (2002) Selenium supplementation in patients with autoimmune thyroidities decreases thyroid peroxidase antibody concentrations. J Clin. Endocrinol Metab 87 1687-1691. 

Note-. UIE, urinary iodine exoretion. TSH, thyrotropin fT4, free thyroxine. TPO-Ab, Anti-thyroid peroxidase antibodies. Values are expressed as mean ( SD) exoept for TPO-Ab (number of oases and peroentages). (a) p < 0.05 for the differenoes. (b) No signifioant differenoes. 

TPO-Ab Thyroid peroxidase antibody TSH Thyroid-stimulating hormone... 

TPOAb Anti-thyroid peroxidase antibody USI Universal salt iodization... 

Endocrine In a retrospective study of 260 patients who received interferon-I-ribavirin for hepatitis C infection 10% developed a suppressed serum TSH (0.8% Graves disease, 9.6% transient thyroiditis) and 12% developed a raised serum TSH 1.5% developed permanently hypothyroidism and requiring levothyroxine [49 ]. Women had a relative risk of thyroid dysfunction of 1.96 (95% Cl = 1.8, 3.0). A serum TSH of 1.75 mU/1 or more and a positive thyroid peroxidase antibody titer before therapy were associated with relative risks of 6.0 (95% Cl=3.0, 13) and 4.4 (95% Cl = 2.6, 6.5) respectively. The combination of baseline TSH and thyroid peroxidase antibody data predicted progression to thyroid dysfunction with a sensitivity of 95%. 

Urinary iodide concentrations were determined with an iodide-selective ion electrode(iodide-electrode, radiometer, Copenhagen, Denmark)The anti-thyroglobulin and -thyroid peroxidase antibodies were determined by highly sensitive ra-dioimmuno assay. 

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