Thyroid hormones children

Dorn, L.D., Burgess, E.S., Dichek, H.L., Putnam, F.W., Chrousos, G.P., and Gold, P.W. (1996) Thyroid hormone concentrations in depressed and nondepressed adolescents group differences and behavioral relations [see comments]. / Am Acad Child Adolesc Psychiatry 35 299-306. 

Spurious hyperthyroidism occurred in a child taking thyroid hormone and imipramine for enuresis (89). The ability of thyroid hormone to increase receptor sensitivity to catecholamines has long been known, and has been used to enhance the clinical response in some refractory patients, especially women. 

Thyroid function tests are often altered by somatropin because of increased conversion of T4 to T3, but this is clinically insignificant at low doses (SEDA-21, 453). One child with Prader-Willi syndrome had a fall in serum thyroxine concentration during somatropin therapy and needed thyroxine replacement (33). Hypothyroidism developed in 11 of 46 growth hormone-deficient children treated with somatropin (34). Prior abnormalities in hypothalamic-pituitary function and alterations in thyroid hormone metabolism, probably both, contributed to the high incidence of hypothyroidism, which was similar to that in previous studies. 

A lack of iodine can cause other problems too. For example, thyroid hormones are needed for normal brain development in an unborn child. They are also needed to continue that development after birth. People who do not include enough iodine in their diet do not develop... 

Hypothyroidism can lead to a variety of end-organ effects and a wide range of disease severity, from entirely asymptomatic individuals to patients in coma with multisystem failure. In the adult, manifestations of hypothyroidism are varied and nonspecific. In the child, thyroid hormone deficiency may manifest as growth retardation. 

Calamita A, et al. Plasma levels of transthyretin and retinol-binding protein in Child-A cirrhotic patients in relation to protein-calorie status and plasma amino acids, zinc, vitamin A and plasma thyroid hormones. Arq Gastroenterol 1997 34 139-147. 

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