Anemia thyroid hormones

Laboratory testing (e.g., thyroid function, anemia, gonadal hormones)... 

Beard JL, Green W and Fich CA (1984) Effects of anemia and iron deficiency on thyroid hormone levels and thermoregulation during cold exposure. Am J Physiol 247 R114-R119. 

Leukocytosis Apiastic anemia agranuiocytosis Thrombocytopenia Thyroid hormones (decreased) Ca "... 

It has also been mentioned that salt iodization efficacy, the preferred strategy for IDD, might be influenced by ID, because this disorder impairs thyroid metabolism (WHO, 2001, Zimmermann et al., 2000). It has been observed that two initial steps in thyroid hormone synthesis are catalyzed by Fe-dependent thyroid peroxidase (TPO). One Fe-defl-ciency anemia study in rats showed reduced TPO activity, and decreased plasma T4 and triiodothyronine (T3) levels (Hess et al, 2002). IDA may also alter the central nervous systems thyroid metabolism control, and reduce T4 to T3 peripheral conversion (Beard etal, 1998), modify nuclear T3 binding (Smith et al, 1994), and increase circulating thyrotropin (TSH) (Beard et at, 1990). The therapeutic response to oral iodized oil is impaired in children with IDA compared with Fe-sufficient children (Zimmermann et al, 2000). 

They included 330 school-aged children with a mean age of 14. Free triiodothyronine, free tetraiodothyronine and thyrotropin levels, Hb and mean corpuscular volume, Fe and total Fe-binding capacity concentration and ferritin levels were determined. They found that thyroid hormone levels of the children with anemia were not significantly different compared to children without anemia. No significant correlation was found between thyroid hormones and Fe status, and they concluded that the thyroid hormone profile was not significantly affected. As a result, this study showed no correlation between Fe status and thyroid hormone levels. 

Iodine is an essential component of thyroid hormone either low or high intake may lead to thyroid disease. Currently, intake of seaweed, a low-calorie food containing sufficient calcium, potassium, iron and vegetable fibers, has been recommended for the prevention of ischemic heart diseases, cerebrovascular diseases, dys-hpidemia, diabetes mellitus, hypertension, metabofic syndrome and obesity, as well as for osteoporosis and iron-deficiency anemia (Mizukami et ai, 1993). Besides, salt has been iodized, and as a result, iodine intake has increased throughout the world (Zhao et ai, 1998). 

A 31-year-old woman developed diffuse musculoskeletal pain. She had been taking calcium and dihydrota-chysterol up to 4 mg/day for 6 months for hypoparathyroidism after subtotal thyroid resection. She had severe hypercalcemia (4.1 mmol/1), no detectable intact parathyroid hormone, renal insufficiency (serum creatinine 486 pmol/l), and a normochromic anemia (6.6 g/dl). Rehydration and forced diuresis initially improved renal function and reduced the serum calcium concentration, but the calcium concentration after 4 weeks was still 3.0 mmol/1 and it did not normalize until she was given a single intravenous dose of pamidronate 15 mg. 

Peripheral edema insomnia, headache fever, chills lipid abnormalities, increased triglycerides, cholesterol, reduced high-density lipoproteins hypothyroidism (reduced thyroxine, thyroid-stimulating hormone) diarrhea low emetogenic potential leukopenia and anemia dry skin increased liver function tests pancreatitis... 

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