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Thyroid hormone systemic factors affecting

There is no discrete target tissue for thyroid hormones virtually every cell in the body is affected by thyroid hormones in some way. These hormones are intimately involved in the maintenance of normal function in virtually every cell type, including cellular responsiveness to other hormones, to the availability of metabolic substrates, to growth factors, and so on. Thyroid dysfunction can produce dramatic changes in the metabolism of proteins, carbohydrates, and lipids at the cellular level that can have repercussions for the operation of the cardiovascular, gastrointestinal, musculoskeletal, reproductive, and nervous systems. Some of the clinical manifestations of thyroid dysfunction are presented next in the discussions of hypothyroid and hyperthyroid states. [Pg.746]

Cholesterol biosynthesis is affected by dietary and hormonal factors as well as by various external influences. Cholesterogenesis is enhanced by radiation, thyroid hormones, hypophysectomy, various metal ions and surface active agents. Biosynthesis is inhibited by fasting, thyroidectomy, vanadium salts, and by feeding of cholesterol or some of its steroid precursors. These influences were reviewed by Kritchevsky et al. (1960). In most cases cholesterol synthesis from acetate is more severely inhibited than is synthesis from mevalonate, suggesting that the inhibition occurs at an early step in cholesterol biosynthesis. The inhibition of cholesterol biosynthesis by cholesterol feeding was shown to possess the characteristics of a negative feedback control system (Bucher et al., 1959). [Pg.73]


See other pages where Thyroid hormone systemic factors affecting is mentioned: [Pg.1373]    [Pg.826]    [Pg.96]    [Pg.1429]    [Pg.52]    [Pg.536]    [Pg.304]   
See also in sourсe #XX -- [ Pg.982 ]




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