Thyroid hormone responsive

White, D. M., et al. (1997). Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. J. Biol. Chem. 272, 14387-93. Yamashima, T., et al. (1997). Prostaglandin D synthase (beta-trace) in human... 

Model of the interaction of T3 with the T3 receptor. A Inactive phase —the unliganded T3 receptor dimer bound to the thyroid hormone response element (TRE) along with corepressors acts as a suppressor of gene transcription. B Active phase — T3 and T4... 

Tagging and recovery of associated proteins, as in RNA-TRAP also thrombin receptor activation peptide Thyroid hormone response elements Thyrotropin-releasing hormone... 

Figure 16.31. The Promoter of the Phosphoenolpyruvate Carhoxykinase Gene. This promoter is approximately 500 bp in length and contains regulatory sequences (response elements) that mediate the action of several hormones. IRE, insulin response element GRE, glucocorticoid response element TRE, thyroid hormone response element CREI and CREII, cAMP response elements. [After M. M. McGrane, J. S Jun, Y. M. Patel, and R. W. Hanson. Trends Biochem. Sci. 17(1992) 40.]...

Feng, J., Orlow.ski, J., and Lingrcl,). B. (1993). Identification of a functional thyroid hormone response element in the upstream flanking region of the human Na,K-ATPase al gene, JVuef. Adds Res. 21, 2619-2626. 

Olson, D. E, and Koenig, R. J. (1997). 5 -Flanking sequences in thyroid hormone response element hal(. sites determine the requirement of retinoid X receptor for receptor-mediate gpne expression. J. Bioi. Chm. 272,9907-9914. 

Thyroid Na /l" symportcr. J- Biol. Otem. 272, 2723(1-27236-Evans, R, M, (198S). The steroid and thyroid hormone response superfamily. Scieww 240, 889-895. 

Sap J, Munoz A, Schmitt J, Stunnenberg H, Vennstrom B. 1989. Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature 340 242 14... 

Thyroid hormone has multiple effects on the cardiovascular system with various physiological consequences. Several genes that encode important regulatory and structural proteins in the heart have been shown to be thyroid hormone responsive. Thyroid hormone increases cardiac contractility, induces vasorelaxation and angiogenesis, prevents fibrosis and has favorable effects on lipid metabolism (reviewed by Pantos73). 

This promoter is approximately 500 bp in length and contains regulatory sequences (response elements) that mediate the action of several hormones. Abbreviations IRE, insulin response element GRE, glucocorticoid response element TRE, thyroid hormone response element CREI and CREII, cAMP response elements. 

Drover, V.A., Wong, N.C., Agellon, L.B. 2002. A distinct thyroid hormone response element mediates repression of the human cholesterol 7a-hydroxylase (CYP7AI) gene promoter. Mol. Endocrinol. 16 ... 

Two distinct genes encode 2 families of TRs, TRa and TRp, and both genes encode multiple receptor isoforms. Certain isoforms (e.g., TR j and TRPj) are found in virtually all thyroid hormone-responsive tissues, whereas TRp is expressed only in the anterior pituitary. Resistance to thyroid hormone has been described in patients with mutations in the TRp gene. In addition to nuclear receptor-mediated actions, there are several well-characterized, nongenomic actions of thyroid hormones, including those occurring at the plasma membrane and on the cellular cytoarchitecture. 

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