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Thyroid gland function disrupters

Zebrafish A Vertebrate Model for Screening Thyroid Gland Function Disrupters.. 421... [Pg.415]

Fig. 1 Thyroid hormone synthesis in a thyroid follicular cell. NIS and TPO (organification and coupling reaction) have been marked in red dashed line as the two main targets for direct thyroid gland function disrupters. DEHALl iodotyrosine dehalogenase 1, DIT diiodotyrosine, DUOX2 dual oxidase 2, MIT monoiodotyrosine, Na/K-ATPase sodium-potassium ATPase, NIS sodium-iodide symporter, PSD pendrin, TG thyroglobulin, TPO thyroperoxidase. Reprinted from [7] with permission from Elsevier... Fig. 1 Thyroid hormone synthesis in a thyroid follicular cell. NIS and TPO (organification and coupling reaction) have been marked in red dashed line as the two main targets for direct thyroid gland function disrupters. DEHALl iodotyrosine dehalogenase 1, DIT diiodotyrosine, DUOX2 dual oxidase 2, MIT monoiodotyrosine, Na/K-ATPase sodium-potassium ATPase, NIS sodium-iodide symporter, PSD pendrin, TG thyroglobulin, TPO thyroperoxidase. Reprinted from [7] with permission from Elsevier...
Fig. 5 Heat-map summarizing mammalian versus zebrafish eleutheroembryo responses using 16 known or suspected direct-TGFDs with different modes of action. Red indicates thyroid gland function disrupting activity Green indicates that the chemical is not a TGFD... Fig. 5 Heat-map summarizing mammalian versus zebrafish eleutheroembryo responses using 16 known or suspected direct-TGFDs with different modes of action. Red indicates thyroid gland function disrupting activity Green indicates that the chemical is not a TGFD...
Disrupting Effects of Single and Combined Emerging Pollutants on Thyroid Gland Function... [Pg.415]

IT4C, which emphasizes the risk for the thyroid gland function of the mixture of chemicals with thyroid disrupting activity. [Pg.430]

Amphibians. Amphibians are highly susceptible to endocrine disruption during development of the larval form and during metamorphosis. The action of metamorphosis is triggered and controlled by the thyroid gland via an increase in triiodothyronine and a decrease in thyroxine, and differs greatly between oviparous and viviparous species. Experimentally, it has been shown that disruption during this sensitive period can lead to malformations and adverse impacts on immune and reproductive functions. [Pg.72]

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See also in sourсe #XX -- [ Pg.395 , Pg.415 , Pg.417 ]



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