Thromboxan receptor

Thromboxane receptor Inhibits TxA2 receptor-associated G protein activation... [Pg.237]

Recently, it was shown that the thromboxane receptor itself is a substrate ofcGMP-PK and cAMP-PK in HEK293 cells, HEL cells, or with purified enzymes in vitro. Phosphorylation of its cytoplasmic carboxyterminal domain prevented the thromboxane receptor from coupling to and activating G-proteins [36, 37]. For intact platelets, TxA2 receptor phosphorylation has not yet been shown, however, it would provide another explanation for the inhibition of PLC activation and subsequent intracellular Ca2+ elevation and granule secretion in response to cyclic nucleotides. [Pg.240]

Fig. (6). Vasoconstrictor mechanism of myricetin. PLA2 phospholipase A2 PL phospholipids AA arachidonic acid COX cyclooxygenase PGG2 prostaglandin G2 PGES prostaglandin endoperoxide synthase PGH2 prostaglandin Hi TXS Thromboxane synthase TXA2 Thromboxane A2 Tp Thromboxane receptor PKC protein kinase C.

Zucker TR Bonisch D, Muck S, et al. Thrombin-induced mito-genesis in coronary artery smooth muscle cells is potentiated by thromboxane A2 and involves upregulation of thromboxane receptor mRNA, Circulation 1998 97 589-595. [Pg.91]

A ferret model of acute arterial thrombosis was developed by Schumacher et al. (1996a,b). A 10-min anodal electrical stimulation of 1 mA was delivered to the external surface of the carotid artery while measuring carotid blood flow. This produced an occlusive thrombus in all vehicle treated ferrets within 41 3 min with an average weight of 8 1 mg. Thrombus weight was reduced by aspirin or a thromboxan receptor antagonist. [Pg.285]

Pratico D, Smyth EM, Violi F, Fitzgerald GA. Local amplification of platelet function by 8-Epi prostaglandin F2 alpha is not mediated by thromboxane receptor isoforms. J. Biol. Chem. 1996 271 14916. [Pg.824]

Gerhard J. Johnson, M.D. is Professor of Medicine, University of Minnesota Medical School, and Staff Physician, Hematology/Oncology Section, Medical Service, Veterans Affairs Medical Center, Miimeapolis, Minnesota. His platelet research program, funded by VA Merit l view and NIH grants since 1972, has focused on the study of platelet signal transduction via thromboxane receptors, with emphasis on the study of dog platelets. He has served as Chairman of the VA Merit Review Board for Hematology and the Subcommittee on Animal Models of the Scientific and Standardization Committee, ISTH. [Pg.38]

Blackman SC, Dawscm G, Antcmakis K, Le Brdon GC. The identification and characterization of oligodendrocyte thromboxane receptors. J Biol Chem 1998 273 475-83... [Pg.68]

Abe T, Takeuchi K, Takahadii N, Tsutsuni E, Taniyama Y, Abe K. Rat kidney thromboxane receptor molecular dealing, signal transduction, and intrarenal expression localizaticm. J Clin Invest 1995 96 657-64... [Pg.69]

D Angelo DD, Eubank JJ, Davis MG, Dom II GW. Mutagenic analysis of platelet thromboxane receptor cysteines. Roles in ligand binding and receptor-effector coupling. JBiol Chem 1996 271 6233-40... [Pg.69]

Habib A, Vesa R, Crfrninon C, Maciouf J, FitzGerald GA. R id, agonist-dependent phosphorylation in vivo of human thromboxane receptor isoforms. J Biol Chem 1997 272 7191-200... [Pg.69]

D Angelo DD, Davis MG, Houser WA, Eubank II, Ritchie ME, Dom II GW. Characterization of 5 end of human thromboxane receptor gene. Circ Res 1995 77 466-74... [Pg.69]

Kinsella BT, O Mahony DJ, FitzGerald GA. Phosphorylation and r ulated expression of the human thromboxane receptor. J Biol Chem 1994 269 29914-9... [Pg.70]

Spumey RF, Coffinan TM. Hie C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line. J Pharmacol Exp Ther 1997 283 207-15... [Pg.71]

Aimstrong RA, Jones RL, Wilson NH. Ligand binding to thromboxane receptors on human platelets correlation with biological activity. Br J Phannacol 1983 79 953-64... [Pg.72]

Armstrong RA, Jones RL, Pees ati V, Will SG, Wilson NH. Competitive antagcaiism at thromboxane receptors in human platelets Br J Miamaool 1985 84 595-607... [Pg.72]

Spum RF. Effedofreceptor number on desenatizationofthe mouse thromboxane receptor. Biocfaem Pharmacol 1998 55 1271-81... [Pg.74]

Collier A, Tymkewycz P, Armstrong R, Young RJ, Jones RL, Oarice BF. Increased platelet thromboxane receptor sensitivity in diabetic patients with proliferative retinopathy. Diabetologia 1986 29 471-4... [Pg.78]

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