Thrombosis molecular mechanisms

Symons, M., Derry, J.M.J., Karlak, B., Jiang, S., Lemahieu, B., McCormick, R, Franke, U. and Abo, A. (1996). Wiskott-Aldrich syndrome protein, a novel effector for the GTPase Cdc42Hs, is implicated in actin polymerization. Cell 84, 723-734. Tan, P., Luscinskas, F.W and Homer-Vanniasinkam, S. (1999). Cellular and molecular mechanisms of inflammation and thrombosis. Eur. J. Vase. Endovasc. Surg. 17, 373-389. 

Without going into the molecular defects in other coagulation factors, suffice it to say that our current understanding of mechanisms leading to the clinical expression of thrombosis and bleeding has been enhanced by the knowledge of such mutations. 

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